Good watch, might watch again, and can recommend.
I really like Jeff Garlin and Natasha Lyonne, they play really well off of one another, but every other character just seems like a throw away, even Steve Weber and Leah Remini, whom I both generally like as well.
I like a good mystery, and this movie proves there are a lot of fun, interesting ways to go about doing one, but it is somewhat unsatisfying when you're not onboard with the character motivations. Yes, Handsome is solving a crime, and the killer is an awful person, but the victim wasn't exactly great. Everyone else involved was kind of a jerk too, but in some "quirky" way.
While we see Handsome investigate the crime, too much of the discovery happens in the "beautiful mind" space (surprising reminds me of "Green Hornet"), we get little bits and pieces, but we're not really along for the ride.
While I appreciate it being innovative, normally we get some kind of narrative, or the detective will "mentally re-play" events laying out what we do or do not know, and not having that feels more absent than innovative. Instead we get a sort of recap without "capping".
In "Clue", you get that ridiculous multi-ended re-cap, but in addition to having silent clues, they're actively putting together leads and evidence as to what is happening and who might be next.
It's not that it didn't happen, but thinking back on it, none it felt meaningful at all. Then there is the dead plot line: I know it was for a joke, but it fell flat for me, and I honestly felt relieved when I think I was supposed to feel pity / sadness.
There are a lot of movies out there to watch, this is good, I think you'll enjoy it, but there are a lot of other movies that might be a little better.