Andrea (Pierfrancesco Favino) and Sofia (Kasia Smutniak) are a lovely couple, indeed they were. Married for ten years in crisis, they think of divorce. But as a result of a scientific experiment by Andrea suddenly they find themselves one inside the body of the other. Literally. Andrea is Sofia and Sofia is Andrea. With no choice but to live each other's existence and everyday life. You in the shoes of him, a brilliant neurosurgeon who carries out an experiment on the human brain, he in the shoes of her ambitious TV presenter on the rise.